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KMID : 1161420190220050479
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Journal of Medicinal Food
2019 Volume.22 No. 5 p.479 ~ p.489
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A Low-Glycemic, Mediterranean Diet and Lifestyle Modification Program with Targeted Nutraceuticals Reduces Body Weight, Improves Cardiometabolic Variables and Longevity Biomarkers in Overweight Subjects: A 13-Week Observational Trial
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Tripp Matthew L.
Dahlberg Clinton J.
Eliason Sarah
Lamb Joseph J.
Ou Joseph J.
Gao Wei
Bhandari Jay
Graham David
Dudleenamjil Enkhmart
Babish John G.
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Abstract
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Among the comorbidities of high body mass index, cardiovascular disease continued to be the leading cause of death and disability globally in 2015, while type 2 diabetes remained second. The primary objectives of this observational study were to confirm the safety, tolerability, and efficacy of our calorie-restricted Mediterranean diet with targeted dietary supplementation (PROG1) using globally recognized dietary supplementation. Fifty healthy overweight and obese subjects with cardiometabolic risk factors were assigned a modified Mediterranean diet, including protein shakes and targeted supplementation (PROG2), providing ∼68?76% of subject estimated calorie requirements. Salivary nitrite was assessed weekly and key cardiometabolic metrics were recorded at baseline and weeks 9 and 13. PROG2 was well tolerated with 86% compliance. The most common adverse effects were bloating, flatulence, and constipation, which were self-limiting. Subjects exhibited decreases (P?
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KEYWORD
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low-glycemic load diet, nitric oxide, obesity, polyphenols
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